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Trial SURPASS-2 (NEJM 2021) Population 1,879 adults with T2D vs semaglutide 1 mg

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The changes in the rating scale scores indicate the presence of moderate depression and anxiety symptoms consistent with major depression and GAD and the presence of a chronic fatigue syndrome (lasting 2–3 months), including chronic fatigue, insomnia, autonomic and gastro-intestinal symptoms, and, to a lesser extent, cognitive impairments